The monkeypox outbreak is spreading with alarming speed. Ideally, it should have been nipped in the bud when the first cases appeared in May and June outside West and Central Africa, where monkeypox has been endemic for decades. Now the caseload has expanded to more than 11,000, including 1,470 in the United States, and is expected to increase in the weeks ahead. The lessons of the coronavirus pandemic should be taken to heart and should result in a more rapid response.